Cancer is a moving target

Resistance can develop to even the most targeted medicines, necessitating new strategies and solutions. I’m a MD/PhD student in year three of my clinical training post-PhD, grateful for the opportunity to work on these critical problems. My science falls into the following areas:

1 – Evaluating drug combination synergy

I study how best to pick drugs to selectively inhibit multiple co-targets, optimize synergy between orthosteric and allosteric drugs for the same target, and assess bitopic (linked) compounds.

2 – Understanding drug resistance

I use structural, biochemical and biophysical technqiues to understand how mutations induce drug resistance and which drugs should be used to overcome specific resistance mechanisms. I also study kinetics of protein-drug interactions with a particular emphasis on dissociation processes that are correlated with drug efficacy.

Check out Projects to learn about the science, or About to learn more about me